A risk‐based approach to managing active pharmaceutical ingredients in manufacturing effluent

Heterogeneous Nucleation of Active Pharmaceutical Ingredients on Polymers: Applications in Continuous Pharmaceutical Manufacturing

In this thesis work, we aimed to explore crystallization processes for small molecule API compounds based on engineered polymer surfaces that could be used in continuous manufacturing. First, we identified a library of polymers that can be used and selected PVA as the model polymer based on its solution and film properties. We also illustrated a rational approach for designing and fabricating P...

Recrystallization of Active Pharmaceutical Ingredients

Quantitative analysis of active pharmaceutical ingredients (APIs)

Consequences of New Approach to Chemical Stability Tests to Active Pharmaceutical Ingredients

There is a great need of broaden look on stability tests of active pharmaceutical ingredients (APIs) in comparison with current requirements contained in pharmacopeia. By usage of many modern analytical methods the conception of monitoring the changes of APIs during initial stage of their exposure to harmful factors has been developed. New knowledge must be acquired in terms of identification o...

From Form to Function: Crystallization of Active Pharmaceutical Ingredients

S ince the introduction of aspirin in 1899, and more particularly since the advent of antibiotic ‘‘wonder drugs’’ in the 1940s, society has come to rely on the widespread availability of therapeutic drugs at reasonable prices. It was a tremendous challenge to bring penicillin to market and could not have been done without the simultaneous development of both product and process under the inspir...